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An organ-on-chip device with integrated multimodal sensing

Continuous monitoring of tissue microphysiology is critical in the organ-on-chip (OoC) approach to in-vitro drug screening and disease modeling. Integrated sensing units are therefore particularly convenient; however, sensitive in-situ measurements are challenging due to the inherently small size of OoC devices, the characteristics of commonly used materials, and external hardware setups needed.

We recently demonstrated a silicon-polymer hybrid OoC device that encompasses transparency and biocompatibility of polymers at the sensing area, and the inherently superior electrical characteristics and ability to house active electronics of silicon. This multi-modal device includes floating-gate field-effect transistors (FG-FET) to monitor changes in pH in the sensing area, as well as microelectrodes to monitor the action potential of electrically active cells.
The chips are microfabricated at wafer-scale for potential production upscaling, and their packaging is compatible with commonly-used multi-electrode array measurement setups.

Congratulations to Hande Aydogmus and our co-authors at TU Delft and Leiden University Medical Center for the great work and collaboration!

The full work appeared in Scientific Reports: https://lnkd.in/eAgr4qSu

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