NWO Take-Off Grant for organ-on-a-chip development
- Friday, 21 July 2017
PhD candidates Cinzia Silvestri, William Quiros Solano and Nikolas Gaio (start-up Biond ) and Ronald Dekker have successfully applied for a NWO Take-Off Grant (Phase 1) for organ-on-a-chip development.
"In vitro screening is a fundamental step during drug development. A crucial need of pharmaceutical companies is to assess drug safety at the early stage of the pipeline to identify and eliminate compounds that exhibit a potential for adverse drug reactions. However, at least 462 medicinal products were withdrawn from the market between 1953 and 2014, with consequences for patients, regulatory systems and pharma companies. Therefore, the traditional screening approach, based on in vitro static cell culture assays, is considered not predictive enough. This limitation has increased the interest in more realistic models: Organs-on-chips (OOCs). Organ-on-Chips are micro-fluidics devices designed to simulate in vivo human physiology by promoting cell and tissue growth in vitro.
BIOND developed an innovative microfluidic system for OOCs that provides a dynamic micro-environment suited to highly predictive cell culture models, that allows real-time recording of a comprehensive set of data of the cell culture with a user-friendly interface. In particular, this project will aim at improving the user interface focusing on three main aspects: Usability, Functionality and Versatility"
NWO-High Tech Systems and Materials proposal awarded to ECTM
Sun sensors, which are used to determine the satellite orientation towards the sun, are a vital part of the satellite attitude control. Current commercial available sun sensors are too large and costly to be integrated in the small satellites, e.g., nanosats. Due to the low costs of these satellites, they enable a wide range of applications which otherwise would not be possible or cost-effective. By developing a sun sensor that is fully integrated on a single substrate, the overall size of the sensor can be significantly reduced and costly extra calibration is avoided. By using SiC as material, we secure high performance and high reliability under harsh environment. In addition, the sensor will not be sensitive to reflections of the earth, as it uses the parts of the light spectrum absorbed by the atmosphere.
InForMed selected as success story by the EC
The EU-and industry-funded InForMed project has developed a new platform approach to the innovation chain for next-generation medical devices, giving a boost to European manufacturers, in particular SMEs. The project has established a facility that companies can use to manufacture and test prototype micro medical devices, ensuring European leadership in this vital technology-based sector.